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CTHRC1+ fibroblasts are stimulated by macrophageâsecreted SPP1 to induce excessive collagen deposition in keloids.
- Source :
- Clinical & Translational Medicine; Dec2022, Vol. 12 Issue 12, p1-7, 7p
- Publication Year :
- 2022
-
Abstract
- Dear Editor, Fibrosis is characterized by fibroblast dysfunction and excessive deposition of cell-matrix that affect the normal functioning of the original tissue or organ.[1] The pathogenesis of keloids is complex and remains elusive. Fibroblasts interacted with endothelial cells via I ACKR1 i , while multiple chemokines ( I CXCL2 i , I CCL3L3 i ) secreted by myeloid cells interacted with I DPP4 i in fibroblasts (Figure 4D). (F) Interaction of macrophages and fibroblasts based on molecular patterns indicated that macrophages interact with fibroblasts via SPP1. CTHRC1+ fibroblasts are stimulated by macrophage-secreted SPP1 to induce excessive collagen deposition in keloids. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 20011326
- Volume :
- 12
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Clinical & Translational Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 161005901
- Full Text :
- https://doi.org/10.1002/ctm2.1115