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Degradable Pure Magnesium Used as a Barrier Film for Oral Bone Regeneration.

Authors :
Shan, Xianfeng
Xu, Yu
Kolawole, Sharafadeen Kunle
Wen, Ling
Qi, Zhenwei
Xu, Weiwei
Chen, Junxiu
Source :
Journal of Functional Biomaterials; Dec2022, Vol. 13 Issue 4, p298, 16p
Publication Year :
2022

Abstract

The barrier membrane plays an extremely critical role in guided bone regeneration (GBR), which determines the success or failure of GBR technology. In order to obtain barrier membranes with high mechanical strength and degradability, some researchers have focused on degradable magnesium alloys. However, the degradation rate of pure Mg-based materials in body fluids is rather fast, thus posing an urgent problem to be solved in oral clinics. In this study, a novel micro-arc oxidation (MAO) surface-treated pure Mg membrane was prepared. Electrochemical tests, immersion experiments and in vivo experiments were carried out to investigate its potential use as a barrier membrane. The experimental results showed that the corrosion resistance of a pure Mg membrane treated by MAO is better than that of the uncoated pure Mg. The results of cell experiments showed no obvious cytotoxicity, which suggests the enhanced differentiation of osteoblasts. At the same time, the MAO-Mg membrane showed better biological activity than the pure Ti membrane in the early stage of implantation, exhibiting relatively good bone regeneration ability. Consequently, the MAO membrane has been proven to possess good application prospects for guided bone regeneration. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20794983
Volume :
13
Issue :
4
Database :
Complementary Index
Journal :
Journal of Functional Biomaterials
Publication Type :
Academic Journal
Accession number :
160977874
Full Text :
https://doi.org/10.3390/jfb13040298