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FAST-TWITCH MUSCLE FIBERS HYPERTROPHY IS HAMPERED BY ANTIOXIDANT SUPPLEMENTATION DURING ATROPHY REHABILITATION IN RATS.
- Source :
- Journal of Musculoskeletal Research; Dec2022, Vol. 25 Issue 4, p1-12, 12p
- Publication Year :
- 2022
-
Abstract
- The role of antioxidant supplementation on muscle recovery after disuse is unknown. The aim was to investigate the effect of Vitamin C and E supplementation on muscle recovery after hindlimb suspension. Twenty-two Wistar rats were allocated into 4 groups: exercise with supplementation (VIT, n = 5); exercise with placebo (PLA, n = 5); hindlimb suspension (SUSP, n = 6), and control (CON, n = 6). All groups, except for CON, were submitted to a hindlimb suspension protocol for 10 days. Then, VIT and PLA underwent 10 days of a rehabilitation protocol consisting of exercise on a treadmill. VIT received vitamin C (250 mg/kg/day) and E (360 mg/kg) during rehabilitation. Samples of soleus and tibialis anterior were prepared for cross-sectional area (CSA) and biochemical analysis. Both VIT (1265.6 m μ <superscript>2</superscript>, 95% CI: 1234.6–1290.3) and PLA (1280.9 m μ <superscript>2</superscript>, 95% CI: 1296.4–1354.9) presented higher CSA of the soleus in relation to CON (816.66 m μ <superscript>2</superscript>, 95% CI: 866.3–904.0, P < 0.05) with no difference between them. Both VIT (1276.9 m μ <superscript>2</superscript>, 95% CI: 1378.7–1484.6) and PLA (1573.3 m μ <superscript>2</superscript>, 95% CI: 1553.9–1651.5) presented higher tibialis anterior CSA in relation to CON (1041.56 m μ <superscript>2</superscript>, 95% CI: 1119.1–1185.2, P < 0.05). In this muscle, CSA of PLA was higher than VIT (P < 0.05). Vitamin's supplementation attenuated tibialis anterior hypertrophy following the rehabilitation protocol. [ABSTRACT FROM AUTHOR]
- Subjects :
- MUSCULAR hypertrophy
DIETARY supplements
TIBIALIS anterior
VITAMIN E
VITAMIN C
Subjects
Details
- Language :
- English
- ISSN :
- 02189577
- Volume :
- 25
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Musculoskeletal Research
- Publication Type :
- Academic Journal
- Accession number :
- 160737007
- Full Text :
- https://doi.org/10.1142/S0218957722500117