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Protective effects of melatonin on female rat ovary treated with nonylphenol.

Protective effects of melatonin on female rat ovary treated with nonylphenol.

Authors :
Goktepe, Ozge
Balcioglu, Esra
Baran, Munevver
Cengiz, Ozge
Ceyhan, Ayse
Suna, Pinar Alisan
Bolat, Demet
Yalcin, Betul
Yay, Arzu
Source :
Biotechnic & Histochemistry; Jan2023, Vol. 98 Issue 1, p13-19, 7p
Publication Year :
2023

Abstract

We investigated using histochemistry and immunohistochemistry ovarian damage caused by nonylphenol (NP) and the protective effect of melatonin treatment of NP induced ovarian damage. We used 21 female rats divided randomly into three groups: control, NP and melatonin + NP. Histopathological examination of the ovaries, and counting and classification of follicles were performed using Masson's trichrome staining. Expression of anti-Mullerian hormone (AMH), Bax, Bcl-2 and caspase-3 was detected in the ovaries using immunohistochemistry. Melatonin had an ameliorative effect on NP induced follicular atresia and absence of corpora lutea. More follicles were observed in the ovaries of animals treated with melatonin prior to treatment with NP. AMH immunoreactivity was significantly lower in the NP group than in the melatonin + NP group. NP increased immunostaining for Bax, Bcl-2 and caspase-3. Melatonin significantly reduced the increased expression of Bax, Bcl-2 and caspase-3 due to NP exposure. We found that pretreatment with melatonin is beneficial for protecting the ovaries from damage by NP. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10520295
Volume :
98
Issue :
1
Database :
Complementary Index
Journal :
Biotechnic & Histochemistry
Publication Type :
Academic Journal
Accession number :
160676400
Full Text :
https://doi.org/10.1080/10520295.2022.2075566