Preparation of nanofiber membranes loaded with phosphatidylcholine and evaluation of their cell anti-adhesion properties.

By using electrospinning technology, phosphatidylcholine with different mass concentrations was added to polylactic acid and polyglycolic acid for blending spinning, thereby investigating the feasibility of preparing an anti-adhesion membrane for the peritoneal cavity. The fiber morphology, surface composition, mechanical properties, hydrophilic and hydrophobic properties, degradation properties, and anti-cell adhesion properties of the composite film were characterized by field emission scanning electron microscope, infrared spectrum, strength meter, contact angle meter, and cell experiments. The results show that phosphatidylcholine is successfully loaded into the fiber membrane, and the fiber membrane with phosphatidylcholine has good hydrophilicity and appropriate mechanical properties, and can maintain structural integrity after degradation for 28 days, and has good adhesion resistance to L-929 fibroblasts. It shows that the fiber membrane with phosphatidylcholine has potential application in the field of anti-adhesion. [ABSTRACT FROM AUTHOR]