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Comparison of therapeutic efficacy of intralesional platelet-rich plasma and topical alpha-glucoside derivative of trihydroxy benzoic acid in melasma: a randomized controlled study.
- Source :
- Pigment International; Sep-Dec2022, Vol. 9 Issue 3, p188-196, 9p
- Publication Year :
- 2022
-
Abstract
- Background: Melasma is the most common cause of facial melanosis and presents with a complex therapeutic problem. Intralesional platelet-rich plasma (PRP) has shown promising results in hyperpigmentation, whereas alphaglucoside derivative of trihydroxy benzoic acid (THBG) is a newer molecule for the management of pigmentation. Aims and objective: To compare therapeutic effects of PRP and THBG in facial melasma, note any untoward side effects of therapy and evaluate dermoscope as a tool for therapeutic prognosis. Methods: A total of 60 patients were enrolled based on inclusion and exclusion criteria after due written informed consent. After clinical, dermoscopic, and Wood lamp examination with relevant blood investigations, group P was treated by three sittings of intralesional injection of PRP at monthly interval, whereas group B was subjected to local application of THBG twice a day. Intergroup as well as intragroup comparative analyses were performed by subjective scores and dermoscope. Results: The mean of difference between modified melasma area and severity index (mMASI) score at the end of the study (i.e., difference mMASI at 12 and 0 weeks) was 2.21 for group P and 0.18 for group B and on comparison, the Pvalue was <0.0001 which is considered statistically significant. The average %mMASI improvement in group P was 35.05%, whereas in group B, it was 3.18%. On analysis of other parameters, physician global assessment, patient global assessment, and melasma quality of life scale patients of group P showed higher and significant improvements in comparison with group B. Changes in dermoscopic parameters could be appreciated in patients with significant improvement only. Conclusion: There is mild-moderate improvement in melasma (average 35.05%) with PRP with no untoward side effects, whereas THBG did not show any promising result in the treatment of melasma in FT grade IV/V. [ABSTRACT FROM AUTHOR]
- Subjects :
- PLATELET-rich plasma
ANTIFUNGAL agents
STATISTICS
INJECTIONS
GLYCOSIDES
HYPERPIGMENTATION
QUANTITATIVE research
MANN Whitney U Test
TREATMENT effectiveness
RANDOMIZED controlled trials
T-test (Statistics)
PEARSON correlation (Statistics)
DESCRIPTIVE statistics
STATISTICAL sampling
DATA analysis
MELANOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 23495782
- Volume :
- 9
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Pigment International
- Publication Type :
- Academic Journal
- Accession number :
- 160641578
- Full Text :
- https://doi.org/10.4103/pigmentinternational.pigmentinternational_79_20