Is ambient air pollution associated with sarcopenia? Results from a nation-wide cross-sectional study.

Background sarcopenia is a disease that involves the degeneration of muscle strength, muscle mass and physical performance. It remains unknown whether air pollution exposure increases the risk of sarcopenia. Methods the baseline survey of the UK Biobank was used in this study. Sarcopenia was identified according to European Working Group on Sarcopenia in Older People 2 (EWGSOP2) and classified into non-sarcopenia and probable sarcopenia. Land use regressions were used to estimate concentrations of particulate matter (PM_2.5), coarse particles (PM_coarse), PM₁₀, PM_2.5 absorbance, nitrogen dioxide (NO₂) and nitrogen oxides (NO _x). Logistic regression models were applied to estimate the associations between air pollution and sarcopenia and its components. Results out of 352,265 participants, 28,710 (8.2%) were identified with probable sarcopenia. In adjusted models, there were increased odds of probable sarcopenia for each interquartile range increase in PM_2.5 (OR: 1.06; 95% CI: 1.04, 1.07), PM₁₀ (OR: 1.15; 95% CI: 1.13, 1.17), PM_coarse (OR: 1.02; 95% CI:1.01, 1.03), PM_2.5 absorbance (OR: 1.08; 95% CI: 1.07, 1.10), NO₂ (OR: 1.12; 95% CI:1.10, 1.14) and NO _x (OR: 1.06; 95% CI: 1.05, 1.08). Conclusions this study suggests that exposure to ambient air pollution might be one risk factor of sarcopenia. Prospective studies are needed to further confirm our findings. [ABSTRACT FROM AUTHOR]