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α-Glucosidase inhibitory and α-amylase inhibitory activities of compounds isolated from Uvaria rufa Blume.
- Source :
- Natural Product Research; Dec2022, Vol. 36 Issue 23, p6039-6043, 5p
- Publication Year :
- 2022
-
Abstract
- A new C-benzylated flavone, uvariaruflavone (1), along with 13 known compounds (2–14) were isolated from the twig and leaf extracts of Uvaria rufa Blume. Their structures were established by extensive spectroscopic methods. Flavones (5–8) and cyclohexene (10) were isolated from U. rufa for the first time. Most of the isolated compounds were evaluated for their α-glucosidase and α-amylase inhibitory activities. Of these, uvariaruflavone (1) showed the highest α-glucosidase inhibitory activity with an IC<subscript>50</subscript> value of 44.3 µM, while ferrudiol (12) displayed the highest α-amylase inhibitory activity with an IC<subscript>50</subscript> value of 73.5 µM. [ABSTRACT FROM AUTHOR]
- Subjects :
- FLAVONES
ALPHA-glucosidases
CYCLOHEXENE
AMYLASES
TWIGS
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 36
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 160564602
- Full Text :
- https://doi.org/10.1080/14786419.2022.2041010