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Usefulness of ethiodized oil and gelatin sponge particles for delaying the washout of indocyanine green from the liver in swine.

Usefulness of ethiodized oil and gelatin sponge particles for delaying the washout of indocyanine green from the liver in swine.

Authors :
Tanaka, Ryota
Sonomura, Tetsuo
Ueno, Masaki
Koike, Masataka
Makitani, Ayano
Sato, Hirotatsu
Fukuda, Kodai
Higashino, Nobuyuki
Ikoma, Akira
Murata, Shin-ichi
Minamiguchi, Hiroki
Source :
Japanese Journal of Radiology; Dec2022, Vol. 40 Issue 12, p1300-1306, 7p
Publication Year :
2022

Abstract

<bold>Purpose: </bold>To assess the effect of ethiodized oil (EO) and gelatin sponge particles (GS) on delaying the washout of indocyanine green (ICG) from the liver in swine.<bold>Methods: </bold>Fifteen swine were divided into 3 groups: injection of a mixture of ICG and water-soluble contrast medium (CM) followed by embolization with GS (group A), injection of a mixture of ICG and EO (group B) and injection of a mixture of ICG and EO followed by embolization with GS (group C). The liver surface was observed using an infrared camera system during and at 1, 2, 3, and 6 h after the procedure to measure ICG contrast. Livers were removed at 6 h for histopathological examination.<bold>Results: </bold>The contrast ratio between injected and non-injected regions at 6 h was 1.45 ± 0.44 in group A, 1.89 ± 0.37 in group B, and 3.62 ± 0.76 in group C. The contrast ratio in group C was significantly greater than that in groups A and B (P = 0.032 and 0.033, respectively).<bold>Conclusions: </bold>EO and GS delayed the washout of ICG from the liver in swine and may extend intraoperative navigation in clinical use. Indocyanine green (ICG) mixed with ethiodized oil (EO) was injected into the left hepatic artery in swine, and the artery was embolized with gelatin sponge particles (GS). We confirmed that ICG remained in the liver parenchyma up to 6 h after the procedure. EO and GS delayed the washout of ICG from the liver in swine. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18671071
Volume :
40
Issue :
12
Database :
Complementary Index
Journal :
Japanese Journal of Radiology
Publication Type :
Academic Journal
Accession number :
160562509
Full Text :
https://doi.org/10.1007/s11604-022-01315-9