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Is it necessary for patients with potentially resectable esophageal squamous cell cancer to receive routine preoperative brain MRI/CT?
- Source :
- Thoracic Cancer; Dec2022, Vol. 13 Issue 23, p3304-3309, 6p
- Publication Year :
- 2022
-
Abstract
- Background: This study aimed to investigate the value and efficiency of routine brain MRI or CT in the preoperative workup for patients with potentially resectable (cT1‐4aN0‐3) thoracic esophageal squamous cell cancer (ESCC). Methods: This was a prospective cross‐sectional clinical trial (ChiCTR1800020304). A total of 385 patients with potentially resectable (cT1‐4aN0‐3) thoracic ESCC diagnosed from October 2018 to August 2020 were included. Plain brain MRI or CT was performed preoperatively to detect brain metastases (BrM). The primary endpoint was BrM detected by imaging. Results: Of all 385 patients, the rate of positive brain MRI/CT findings was 1% (n = 4). BrM Patients received chemoradiotherapy, and the median OS was 6 months (95% CI: 4.303–7.697). All 381 remaining patients with initial negative brain MRI/CT diagnosis revealed no brain‐associated symptoms within 6 months. The median follow‐up for patients without BrM was 20 months (range, from 6 to 32). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of plain MRI or CT to detect BrM were all 100%. Conclusions: Preoperative plain MRI or CT is an effective method to detect BrM for potentially resectable (cT1‐4aN0‐3) thoracic ESCC. However, due to the low incidence, the value of brain MRI/CT as a routinely preoperational examination in potentially resectable esophageal squamous cell cancer is rather limited. Therefore, preoperative brain MRI/CT should not be recommended as a routine preoperative examination for ESCC. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREOPERATIVE care
BRAIN
CLINICAL trials
CONFIDENCE intervals
CROSS-sectional method
MAGNETIC resonance imaging
METASTASIS
FISHER exact test
CHEMORADIOTHERAPY
DESCRIPTIVE statistics
CHI-squared test
COMPUTED tomography
DATA analysis software
SQUAMOUS cell carcinoma
ESOPHAGEAL cancer
LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 17597706
- Volume :
- 13
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Thoracic Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 160529249
- Full Text :
- https://doi.org/10.1111/1759-7714.14686