The clinical analysis of new‐onset status epilepticus.

Objective: To investigate and analyze the etiology and prognosis of patients with new‐onset status epilepticus (NOSE). Methods: We conducted a retrospective analysis of all adult patients (≧16 years old) who were admitted to Sichuan Provincial People's Hospital between January 2018 and December 2020 with status epilepticus (SE) and no prior epilepsy history. Results: We collected data from 85 patients, aged from 16 to 90 years, of whom 49 were male and 36 were female. Fifty‐five of these cases (64.7%) were younger than 60 years of age. Acute symptomatic SE was mostly seen in the NOSE (53.9%), followed by unknown SE (25.9%), progressive SE (11.8%), and remote SE (9.4%). The differences in the etiology of NOSE between age groups were statistically significant (P <.05). For the young, the main etiology remained unknown (36.3%), followed by autoimmune‐related SE (16.4%); in the elderly, the primary etiology was central nervous system (CNS) infection (23.3%), followed by cerebrovascular disease (20%), and intracranial tumors (20%). Normal imaging was mostly seen in young people with NOSE (P <.001). Regarding outcome parameters and risk factors in patients with NOSE, adverse outcome was associated with age (OR = 3.5, 95% CI = 0.108–0.758, P =.012), co‐infection (OR = 4.5, 95% CI = 0.083–0.599, P =.003), and tracheal intubation (OR = 6.318, 95% CI = 0.060–0.204, P =.011). Significance: In our cohort, intracranial tumors, CNS infections, and cerebrovascular disease were the predominant causes of NOSE in the elderly, while autoimmune encephalitis was the largest recognized cause of NOSE in young patients. In addition, imaging varies with age. According to the data, preventing infections may enhance patient prognosis because greater infection rates are connected with less favorable results. Meanwhile, age and mechanical ventilation are related to the prognosis of NOSE. [ABSTRACT FROM AUTHOR]