'Population pharmacokinetics and dosing optimization of mezlocillin in neonates and young infants'-authors' response.

The effects of postnatal age (PNA) and serum creatinine concentration were also tested on the basis of the equations from the previous study.[2] HT <math xmlns="http://www.w3.org/1998/Math/MathML"><mi>T</mi><mi>S</mi><mi>C</mi><mi>r</mi><mo>=</mo><mo>-</mo><mn>2.849</mn><mo>-</mo><mrow><mi mathvariant="normal">PMA</mi><mspace width="0.25em" /></mrow><mo stretchy="false">(</mo><mrow><mrow><mi mathvariant="normal">weeks</mi></mrow></mrow><mo stretchy="false">)</mo><mo>+</mo><mn>166.48</mn></math> ht HT <math xmlns="http://www.w3.org/1998/Math/MathML"><msup><mrow><mo>(</mo><mrow><mstyle displaystyle="true" scriptlevel="0"><mrow><mfrac><mrow><mi>M</mi><mi>S</mi><mi>C</mi><mi>r</mi></mrow><mrow><mi>T</mi><mi>S</mi><mi>C</mi><mi>r</mi></mrow></mfrac></mrow></mstyle></mrow><mo>)</mo></mrow><mi mathvariant="normal"> </mi></msup></math> ht HT <math xmlns="http://www.w3.org/1998/Math/MathML"><mi>P</mi><mi>o</mi><mi>s</mi><mi>t</mi><mi>n</mi><mi>a</mi><mi>t</mi><mi>a</mi><mi>l</mi><mspace width="0.25em" /><mi>a</mi><mi>g</mi><mi>e</mi><mspace width="0.25em" /><mi>f</mi><mi>u</mi><mi>n</mi><mi>c</mi><mi>t</mi><mi>i</mi><mi>o</mi><mi>n</mi><mo>=</mo><mstyle displaystyle="true" scriptlevel="0"><mrow><mfrac><mrow><mi>P</mi><mi>N</mi><mi>A</mi></mrow><mrow><mi>P</mi><mi>N</mi><msub><mi>A</mi><mn>50</mn></msub><mo>+</mo><mi>P</mi><mi>N</mi><mi>A</mi></mrow></mfrac></mrow></mstyle></math> ht where TSCr is a typical value of serum creatinine for a specific PMA, I MSCr i is measured serum creatinine and I PNA i SB 50 sb is the PNA when clearance has reached 50% of a typical adult's clearance. We thank Dr Standing for his comments on our recently published study[1] on population pharmacokinetics and dosing optimization of mezlocillin in neonates and young infants. [Extracted from the article]