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Chemotherapy‐induced peripheral neuropathy onset is associated with early risk of depression and anxiety in breast cancer survivors.
- Source :
- European Journal of Cancer Care; Nov2022, Vol. 31 Issue 6, p1-9, 9p
- Publication Year :
- 2022
-
Abstract
- Objective: The objective was to assess for an association between chemotherapy‐induced peripheral neuropathy (CIPN) onset and development of depression and anxiety in breast cancer (BrCa) survivors. Methods: A retrospective observational cohort was used and identified from Optum's De‐identified Clinformatics® Data Mart Database years 2012–2015. Three groups of women were derived based on BrCa and CIPN status: BrCa+/CIPN+ (n = 244), BrCa+/CIPN− (n = 8870), and BrCa−/CIPN− (n = 1,125,711). The ratio of the prevalence ratios (RPR) determined if the change in risk of depression and anxiety from the 12‐month preindex period to postindex period I (0–6 months) and II (7–12 months) was different for BrCa+/CIPN+ compared to BrCa+/CIPN− and BrCa−/CIPN−. Results: The adjusted RPR for depression was significantly elevated for BrCa+/CIPN+ compared to BrCa+/CIPN− and BrCa−/CIPN− for postindex periods I (RPR = 1.35 [1.10,1.65] and 1.33 [1.08,1.63], respectively) and II (RPR = 1.53 [1.21,1.94] and 1.50 [1.17,1.93], respectively). The RPR for anxiety was significantly elevated for BrCa+/CIPN+ compared to BrCa+/CIPN− and BrCa−/CIPN− for postindex periods I (RPR = 1.37 [1.12,1.67] and 1.31 [1.06,1.61], respectively) and II (RPR = 1.41 [1.13,1.76] and 1.28 [1.02,1.62], respectively). Conclusions: Among BrCa survivors, CIPN onset is associated with a subsequent increased 12‐month risk of depression and anxiety. Depression and anxiety screening should be considered in BrCa+/CIPN+ survivors, particularly given their known impact on fall risk. The observed association between CIPN and an increased risk of depression and anxiety should be further studied in prospective studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- MENTAL depression risk factors
PERIPHERAL neuropathy
SCIENTIFIC observation
CONFIDENCE intervals
CANCER chemotherapy
RETROSPECTIVE studies
CANCER patients
RISK assessment
RESEARCH funding
DESCRIPTIVE statistics
CHI-squared test
MENTAL depression
ANXIETY
DATA analysis software
BREAST tumors
LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 09615423
- Volume :
- 31
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- European Journal of Cancer Care
- Publication Type :
- Academic Journal
- Accession number :
- 160426702
- Full Text :
- https://doi.org/10.1111/ecc.13648