LRP1: a novel receptor for the transmission of pathological α-Synuclein.

In 2020, through a functional screen of LDLR receptors, Rauch et al. demonstrated that low-density lipoprotein receptor-related protein 1 (LRP1), is a key receptor that mediated the interneuronal spreading of pathological tau. Keywords: LRP1; -Synuclein; Parkinson's disease; Receptor mediated endocytosis EN LRP1 -Synuclein Parkinson's disease Receptor mediated endocytosis 1 3 3 11/29/22 20221126 NES 221126 During the past decade, mountains of evidence support that the transmission of pathological proteins is a shared mechanism for the progression of various neurodegenerative diseases [[1]]. Abbreviations -syn -Synuclein PD Parkinson's Disease DLB dementia with Lewy body AD Alzheimer's disease LAG3 lymphocyte-activation gene 3 PFF preformed fibrils HSPG heparan sulfate proteoglycan Abeta amyloid beta LDLR low-density lipoprotein receptor LRP1 low-density lipoprotein receptor-related protein 1 iPSc induced pluripotent stem cells Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. [Extracted from the article]