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Salivary inflammatory biomarkers are predictive of mild cognitive impairment and Alzheimer's disease in a feasibility study.
- Source :
- Frontiers in Aging Neuroscience; 11/10/2022, Vol. 14, p01-11, 11p
- Publication Year :
- 2022
-
Abstract
- Alzheimer's disease (AD) is an insidious disease. Its distinctive pathology forms over a considerable length of time without symptoms. There is a need to detect this disease, before even subtle changes occur in cognition. Hallmark AD biomarkers, tau and amyloid-b, have shown promising results in CSF and blood. However, detecting early changes in these biomarkers and others will involve screening a wide group of healthy, asymptomatic individuals. Saliva is a feasible alternative. Sample collection is economical, non-invasive and saliva is an abundant source of proteins including tau and amyloid-β. This work sought to extend an earlier promising untargeted mass spectrometry study in saliva from individuals with mild cognitive impairment (MCI) or AD with age- and gender-matched cognitively normal from the South Australian Neurodegenerative Disease cohort. Five proteins, with key roles in inflammation, were chosen from this study and measured by ELISA from individuals with AD (n = 16), MCI (n = 15) and cognitively normal (n = 29). The concentrations of Cystatin-C, Interleukin-1 receptor antagonist, Stratifin, Matrix metalloproteinase 9 and Haptoglobin proteins had altered abundance in saliva from AD and MCI, consistent with the earlier study. Receiver operating characteristic analysis showed that combinations of these proteins demonstrated excellent diagnostic accuracy for distinguishing both MCI (area under curve = 0.97) and AD (area under curve = 0.97) from cognitively normal. These results provide evidence for saliva being a valuable source of biomarkers for early detection of cognitive impairment in individuals on the AD continuum and potentially other neurodegenerative diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROTEIN analysis
ALZHEIMER'S disease diagnosis
SALIVA analysis
BIOMARKERS
PILOT projects
CYTOKINES
STATISTICS
STATISTICAL power analysis
BLOOD proteins
INFLAMMATION
MILD cognitive impairment
INTERLEUKIN-1
ALLELES
REGRESSION analysis
MATRIX metalloproteinases
COMPARATIVE studies
RANDOMIZED controlled trials
RESEARCH funding
MASS spectrometry
APOLIPOPROTEINS
ENZYME-linked immunosorbent assay
DESCRIPTIVE statistics
SENSITIVITY & specificity (Statistics)
GLOBULINS
RECEIVER operating characteristic curves
POLYMERASE chain reaction
DATA analysis
DATA analysis software
STATISTICAL sampling
LONGITUDINAL method
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Volume :
- 14
- Database :
- Complementary Index
- Journal :
- Frontiers in Aging Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 160395475
- Full Text :
- https://doi.org/10.3389/fnagi.2022.1019296