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Effect of Detraining on Telomere Length and Expression Level of TRF1 and TRF2 Genes in Skeletal Muscles of Male Mice.

Effect of Detraining on Telomere Length and Expression Level of TRF1 and TRF2 Genes in Skeletal Muscles of Male Mice.

Authors :
Khodadoost, Mostafa
Shakeryan, Saeed
Arjmand, Sareh
Nikbakht, Masood
Source :
Abstracts of the ICA; 2022, Vol. 5, p92-106, 15p
Publication Year :
2022

Abstract

Background and Objectives This study aims to investigate the effect of detraining on the telomere length in skeletal muscles of male mice. Subjects and Methods The samples were 24 C57BL/6 male mice that were randomly divided into four groups: Base control (n=6), control (n=6), low-intensity training (n=6), and high-intensity training (n=6). The training program was performed for 8 weeks, 5 days per week following 4 weeks of detraining. The factors were measured after DNA and RNA extraction using real time polymerase chain reaction method. The data were analyzed using two-way ANOVA. Results The main effects of muscle type (slow-twitch and fast-twitch) (P=0.825) and detraining type (P=0.062) and their interaction effect (P=0.408) on the expression of TRF1 gene was not significant. The main effects of muscle type (P=0.073) and detraining type (P=0.309) and their interaction effect (P=0.093) on the expression of TRF2 gene was not significant, either. The main effects of muscle type (P=0.763) and detraining type (P=0.053) and their interaction effect (P=0.651) on the telomere length was not significant, either. Conclusion Detraining after high-intensity or low-intensity training affects the telomere length of slowtwitch and fast-twitch muscles equally. It seems that detraining in people with a history of exercise with different intensities has no different effect on skeletal muscles. [ABSTRACT FROM AUTHOR]

Details

Language :
Persian
ISSN :
25702106
Volume :
5
Database :
Complementary Index
Journal :
Abstracts of the ICA
Publication Type :
Academic Journal
Accession number :
160274080
Full Text :
https://doi.org/10.32598/JSMJ.21.1.2719