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Micelles Based on Polyvinyl Alcohol Substituted with Oleic Acid for Targeting of Lipophilic Drugs.
- Source :
- Drug Delivery; Jan/Feb2005, Vol. 12 Issue 1, p21-26, 6p
- Publication Year :
- 2005
-
Abstract
- Polymeric micelles based on polyvinyl alcohol substituted with oleic acid were used as vehicles for progesterone and folic acid. The ability of this amphiphilic polymer to entrap lipophilic drugs and to generate stable micelles in aqueous neutral medium makes it a good candidate for drug delivery. The release of the loaded drugs in acidic environments represents another important property of these systems. Size of micelles, their stability, and their drug-loading capacity were evaluated, as well as the in vitro controlled-release profiles at pH 7.4 and 5.5. [ABSTRACT FROM AUTHOR]
- Subjects :
- MICELLES
POLYVINYL alcohol
VINYL polymers
FOLIC acid
PROGESTERONE
BIOPOLYMERS
Subjects
Details
- Language :
- English
- ISSN :
- 10717544
- Volume :
- 12
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Drug Delivery
- Publication Type :
- Academic Journal
- Accession number :
- 16024732
- Full Text :
- https://doi.org/10.1080/10717540590889646