Pharmacogenomics guided dosing for fluoropyrimidine and irinotecan chemotherapies for patients with cancer (PACIFIC-PGx): study protocol of a multicentre clinical trial.

The article reports that Clinical Pharmacogenetics Implementation Consortium updated best practice guidelines in 2018 for 5-FU and capecitabine dose optimization. Topics include examines CPIC recommended that the four common DPYD genetic variants known to affect DPD enzyme activity should be incorporated as part of a DPD screening program.