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Anticancer ruthenium(II) tris(pyrazolyl)methane complexes with bioactive co-ligands.
- Source :
- Dalton Transactions: An International Journal of Inorganic Chemistry; 11/28/2022, Vol. 51 Issue 44, p17050-17063, 14p
- Publication Year :
- 2022
-
Abstract
- In comparison with Ru<superscript>II</superscript>-arene compounds, the medicinal potential of homologous Ru<superscript>II</superscript>-tpm compounds [tpm = tris(pyrazolyl)methane] is underexplored. Pyridine, 4-pyridinemethanol and four functionalized pyridines, synthesized from the esterification of 4-pyridinemethanol with bioactive carboxylic acids (i.e., ethacrynic acid, ibuprofen, flurbiprofen and naproxen), react with the precursor [RuCl(κ<superscript>3</superscript>-tpm)(PPh<subscript>3</subscript>)<subscript>2</subscript>]Cl (1) to afford [RuCl(κ<superscript>3</superscript>-tpm)(PPh<subscript>3</subscript>)(L)]Cl (2–7, L = pyridine ligand), in 78–91% yields. All products were fully characterized by HR-ESI mass spectrometry, IR and multinuclear NMR spectroscopy and the solid-state structures of two of the complexes, i.e. where L = pyridine and 4-pyridinemethanol, were ascertained by single crystal X-ray diffraction. The {Ru-tpm-PPh<subscript>3</subscript>} assembly is stable in D<subscript>2</subscript>O and in biological medium (DMEM) at 37 °C, with a tendency to slowly dissociate the pyridine ligand. The antiproliferative activity of the complexes was assessed on the cancerous A2780 and A2780cisR cell lines, and the nontumoral HEK 293T cell line; moreover inhibition assays were carried out on the complexes towards COX-2 and GSTP1 enzymes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14779226
- Volume :
- 51
- Issue :
- 44
- Database :
- Complementary Index
- Journal :
- Dalton Transactions: An International Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 160236173
- Full Text :
- https://doi.org/10.1039/d2dt03009h