Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats—Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging.

The heterogeneity of BPA distribution in the tumor tissues suggests the possibility of tumor recurrence for patients because the area with a lower penetration of BPA might receive an insufficient dose for killing tumor cells in BNCT. In addition, the BPA biodistribution image obtained in the present study showed that BPA accumulates evenly in the deep part of the brain tumor, rather than a biased BPA biodistribution due to diffusion from CSF. In our study, we examined the BPA biodistribution in rat brain after BPA infusion via CSF circulation to demonstrate the usefulness of the CSF administration method for brain tumors. We obtained evidence that BPA arrives directly into the brain parenchyma with CSF microcirculation through perivascular spaces by creating images of BPA penetration into the brain parenchyma following administration via CSF. [Extracted from the article]