STUDY ON THE EFFECT OF CYPERUS ROTUNDUS ON OXIDATIVE STRESS INDUCED BY PROPYLTHIOURACIL DRUG IN WHITE MALE RATS.

The aim of this study was to examine the protective role of Cyperus rotundus tubers against propylthiouracil drug induced oxidative stress in male rats. In this experiment, 30 white male rats were used, divided randomly into three main groups, each group included 10 animals as follows: The first group (G1): They were given a physiological saline solution (Nacl) at a concentration of 0.9% and served as control group. The second group (G2): given a Propylthiouracil drug (15 mg / kg of body weight) by oral administration using a special wine syringe for this purpose daily for 30 days. The third group (G3): They were given a Propylthiouracil drug (15 mg / kg of body weight) by oral administration and they were given aqueous extract of Cyperus rotundus tubers (150 mg / kg of body weight) for 30 days. These results shows a significant increase (p<0.05) in the level of MDA and NO with a significant decrease (p < 0.05) in the level of GSH in the G2 in comparison with control group. While, the current results indicated a significant decrease (p< 0.05) in the level of MDA and NO with a significant increase (p < 0.05) in the level of GSH in the G3 in comparison with G2. These results show a significant decrease (p<0.05) in sperm concentration, the percentage of live sperm, the percentage of normal sperm and the percentage of motile sperm and a significant increase (p<0.05) in the percentage of dead sperm in (G2) group in comparison with control group. There was a significant decrease (p< 0.05) in serum GnRH, testosterone level, FSH level, LH level in (G2) group as compared to the control group. While the results showed a significant improvement in the level of hormonal parameters in (G3) group in comparison with (G2) group (Table 3). The results showed that there were no significant differences in the RBC, Hb and PCV in (G2, G3) groups as compared to the control group. [ABSTRACT FROM AUTHOR]