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Case series of chronic spontaneous urticaria following COVID-19 vaccines: an unusual skin manifestation.
- Source :
- European Journal of Clinical Pharmacology; Dec2022, Vol. 78 Issue 12, p1959-1964, 6p, 3 Color Photographs
- Publication Year :
- 2022
-
Abstract
- Background: Urticaria following the COVID-19 vaccine was rarely reported and had a short self-limited resolution. However, there has been relatively little literature published on CSU induced by COVID-19 vaccines. Purpose: We describe a case series of patients who experienced CSU after SARS-CoV-2 vaccination. Methods: A retrospective case series of 10 patients referred to the Department of Clinical Pharmacology of the University of Monastir (January 2021–January 2022) and included for evaluation of urticaria after COVID-19 vaccination. Results: The median age was 31 years and patients were mostly female. Atopy was presented in 3 patients and urticaria was accompanied by angioedema in 6 patients. The median time interval between vaccination and the onset of urticaria was 28.5 h. The offended dose was the first one in 8 patients. The resolution of the eruption was observed at least 2 months later, despite the regular use of a full dose of antihistamine in nine patients. Polynuclear leucocytosis was identified in 5 patients. Anti-TPOAb was positive in one patient after receiving the BNT162b2 vaccine. Total serum IgE was elevated in 4 patients. Skin tests for the suspected vaccine as well as the vaccine excipient were negative. Conclusion: We add to the medical literature ten new cases of chronic spontaneous urticarial reactions following COVID-19 vaccines uncontrolled with high-dose first-generation H1 antihistamines. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00316970
- Volume :
- 78
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- European Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 160141329
- Full Text :
- https://doi.org/10.1007/s00228-022-03399-8