Synthesis and identification of pyrimidine and oxazepine heterocyclic compounds from alclofenac drug with study anti-corrosion with evaluating of anticancer and biological activity.

This study includes three stages in the synthesis of the hetrocyclic derivative. One stage: the formation of compounds (A1a), (A1b) and (B) using (DCC) and (HOBt) coupling reagents. The second stage: the formation of compounds (A2a, A2b) from oxidation (A1a) and (A1b) using (SiO₂). Third stage: (A3a, A3b) prepred by cyclocondensation (A2a) using ethylacetoacetate and urea. Compound formation (A4a,A4b) synthesized from (A3a, A3b) with ethanol NH2NH2. Preparation of the Schiff base (A5a,A5b)Oxazepine derivatives (A6a,A6b) were synthesized from (A5a,b) with appropriate anhydrides.. Avariety of major uses for prepared compounds such as anti-cancer, anti-corrosion, anti-oxidant and antibacterial action against two forms of bacteria have been used in vitro: Escherchia coli (-G) and Staphylcoccus (+G) bactaria. Compounds classified by such spectroscopic methods H¹NMR, FT-IR and C.H.N analysis. [ABSTRACT FROM AUTHOR]