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Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay.

Authors :
Elbaz, I. M.
Sohaly, M. A.
El-Metwally, H.
Source :
Theory in Biosciences; Nov2022, Vol. 141 Issue 4, p365-374, 10p
Publication Year :
2022

Abstract

In this paper, a new mathematical model that describes the dynamics of the within-host COVID-19 epidemic is formulated. We show the stochastic dynamics of Target-Latent-Infected-Virus free within the human body with discrete delay and noise. Positivity and uniqueness of the solutions are established. Our study shows the extinction and persistence of the disease inside the human body through the stability analysis of the disease-free equilibrium E 0 and the endemic equilibrium E ∗ , respectively. Moreover, we show the impact of delay tactics and noise on the extinction of the disease. The most interesting result is even if the deterministic system is inevitably pandemic at a specific point, extinction will become possible in the stochastic version of our model. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14317613
Volume :
141
Issue :
4
Database :
Complementary Index
Journal :
Theory in Biosciences
Publication Type :
Academic Journal
Accession number :
160074127
Full Text :
https://doi.org/10.1007/s12064-022-00379-5