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Ynamide‐Mediated Peptide Bond Formation: Mechanistic Study and Synthetic Applications.
- Source :
- Angewandte Chemie International Edition; 11/14/2022, Vol. 61 Issue 46, p1-12, 12p
- Publication Year :
- 2022
-
Abstract
- Ynamides, a class of novel coupling reagents for peptide synthesis, facilitated peptide bond formation in a one‐pot, two‐step manner with α‐acyloxyenamide active esters of amino acids as stable intermediates. Ynamide‐mediated peptide synthesis proceeded by a reaction mechanism that is completely different from that of conventional coupling reagents and exhibited superiority in addressing the issue of racemization/epimerization during peptide bond formation. Herein, we present a systematic mechanistic analysis, including kinetics and Brønsted‐type structure–reactivity studies and density functional theory calculations, providing unprecedented mechanistic insight into ynamide‐mediated peptide bond formation. Based on these mechanistic studies, significant improvements were made, and the applicability of ynamide‐mediated peptide bond formation was successfully expanded to peptide fragment condensation, head‐to‐tail cyclization and solid‐phase peptide synthesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 61
- Issue :
- 46
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 160065962
- Full Text :
- https://doi.org/10.1002/anie.202212247