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Pharmaceutical Characterization and in vivo Evaluation of the Possible Anti-Inflammatory Effect of Topical Allopurinol Gel in an Animal Model.
- Source :
- Archives of Razi Institute; Sep/Oct2022, Vol. 77 Issue 5, p1945-1952, 8p
- Publication Year :
- 2022
-
Abstract
- Dermatitis, like inflammation, is a group of common dermatological symptoms and may be associated with systemic and skin diseases. The objective of the current study is to evaluate the potential anti-inflammatory effect of the topical allopurinol against inflammation like skin dermatitis induced by1-isobutyl-1H-imidazo [4,5-c]quinolin-4-amine (IQA) in mice model. The current study allocated the thirty-two mice into four groups (n=8) as follows: i) control group, mice where a white petroleum jelly base applied topically on the dorsal of mice once daily; ii) induction group, mice were received IQA cream (62.5 mg) of (5%) on their back once daily; and iii) the treatment group, mice were treated with both (62.5 mg) of (5%) IQA and (5%) allopurinol gel topically; the betamethasone group, mice were treated with both (62.5 mg) of (5%) IQA and betamethasone ointment topically. All groups were treated daily for seven days period. The allopurinol-treated group exerted nonsignificant differences compared with the induction group in both visional and histopathological changes. The present study revealed that the allopurinolgel (5%) did not affect skin inflammation-induced by IQA in the laboratory mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALLOPURINOL
ANIMAL models in research
LABORATORY mice
PETROLATUM
SKIN inflammation
Subjects
Details
- Language :
- English
- ISSN :
- 03653439
- Volume :
- 77
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Archives of Razi Institute
- Publication Type :
- Academic Journal
- Accession number :
- 160040590
- Full Text :
- https://doi.org/10.22092/ARI.2022.359728.2463