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Palladium‐Catalyzed Cascade Cyclization/Alkylation of Oxime Ethers: Assembly of 4‐Alkylisoxazoles by "Chain‐Walking" Strategy.
- Source :
- Chemistry - An Asian Journal; 11/2/2022, Vol. 17 Issue 21, p1-5, 5p
- Publication Year :
- 2022
-
Abstract
- A reliable and efficient palladium‐catalyzed cascade cyclization/alkylation of oxime ethers with unactivated alkenes is described, affording a whole variety of structurally diverse isoxazole derivatives in moderate to good yields with excellent functional group compatibility. Ionic liquid [Aeim]Br not only acts as an environmentally friendly solvent but also acts as an accelerating agent to provide excess bromine source to eliminate bromomethane from oxime ethers. More importantly, the use of "chain‐walking" strategy provides a novel methodology in organic synthesis to rapid generation of molecular complexity from readily available starting materials. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18614728
- Volume :
- 17
- Issue :
- 21
- Database :
- Complementary Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Academic Journal
- Accession number :
- 160000970
- Full Text :
- https://doi.org/10.1002/asia.202200806