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Emerging ecophenotype: reward anticipation is linked to high-risk behaviours after sexual abuse.
- Source :
- Social Cognitive & Affective Neuroscience; Nov2022, Vol. 17 Issue 11, p1035-1043, 9p
- Publication Year :
- 2022
-
Abstract
- Adolescents frequently engage in high-risk behaviours (HRB) following childhood sexual abuse (CSA). Aberrant reward processes are implicated in HRB, and their underlying fronto-striatal networks are vulnerable to neurodevelopmental changes during adversity representing a promising candidate for understanding links between CSA and HRB. We examined whether fronto-striatal responses during reward anticipation and feedback (i) are altered in depressed adolescents with CSA compared to depressed, non-abused peers and (ii) moderate the relationship between CSA and HRB irrespective of depression. Forty-eight female adolescents {14 with CSA and depression [CSA + major depressive disorder (MDD)]; 17 with MDD but no CSA (MDD); 17 healthy, non-abused controls} completed a monetary reward task during functional magnetic resonance imaging. No differences in fronto-striatal response to reward emerged between CSA + MDD and MDD. Critically, high left nucleus accumbens activation during reward anticipation was associated with greater HRB in CSA + MDD compared to MDD and controls. Low left putamen activation during reward feedback was associated with the absence of HRB in CSA + MDD compared to MDD. Striatal reward responses appear to play a key role in HRB for adolescents with CSA irrespective of depression, providing initial support for a CSA ecophenotype. Such information is pivotal to identify at-risk youth and prevent HRB in adolescents after CSA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17495016
- Volume :
- 17
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Social Cognitive & Affective Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 160000525
- Full Text :
- https://doi.org/10.1093/scan/nsac030