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The risk and prognostic factors for liver metastases in esophageal cancer patients: A large‐cohort based study.
- Source :
- Thoracic Cancer; Nov2022, Vol. 13 Issue 21, p2960-2969, 10p
- Publication Year :
- 2022
-
Abstract
- Background: This retrospective study aimed to explore risk factors for liver metastases (LiM) in patients with esophageal cancer (EC) and to identify prognostic factors in patients initially diagnosed with LiM. Methods: A total of 28 654 EC patients were retrieved from the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2018. A multivariate logistic regression model was utilized to identify risk factors for LiM. A Cox regression model was used to identify prognostic factors for patients with LiM. Results: Of 28 654 EC patients, 4062 (14.2%) had LiM at diagnosis. The median overall survival (OS) for patients with and without LiM was 6.00 (95% CI: 5.70–6.30) months and 15.00 (95% CI: 14.64–15.36) months, respectively. Variables significantly associated with LiM included gender, age, tumor site, histology, tumor grade, tumor size, clinical T stage, clinical N stage, bone metastases (BoM), brain metastases (BrM) and lung metastases (LuM). Variables independently predicting survival for EC patients with LiM were age, histology, tumor grade, BoM, BrM, LuM, and chemotherapy. A risk prediction model and two survival prediction models were then constructed revealing satisfactory predictive accuracy. Conclusions: Based on the largest known cohort of EC, independent predictors of LiM and prognostic indicators of survival for patients with LiM were identified. Two models for predicting survival as well as a risk prediction model were developed with robust predictive accuracy. [ABSTRACT FROM AUTHOR]
- Subjects :
- RISK of metastasis
BRAIN tumor risk factors
REPORTING of diseases
LIVER tumors
CONFIDENCE intervals
MULTIVARIATE analysis
METASTASIS
RETROSPECTIVE studies
LUNG tumors
RISK assessment
CANCER patients
COMPARATIVE studies
BONE tumors
DESCRIPTIVE statistics
PREDICTION models
LOGISTIC regression analysis
STATISTICAL models
ESOPHAGEAL tumors
LONGITUDINAL method
PROPORTIONAL hazards models
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 17597706
- Volume :
- 13
- Issue :
- 21
- Database :
- Complementary Index
- Journal :
- Thoracic Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 159980283
- Full Text :
- https://doi.org/10.1111/1759-7714.14642