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Venous Wall of Patients with Chronic Venous Disease Exhibits a Glycolytic Phenotype.
- Source :
- Journal of Personalized Medicine; Oct2022, Vol. 12 Issue 10, p1642-N.PAG, 11p
- Publication Year :
- 2022
-
Abstract
- Chronic venous disease (CVeD) is a rising medical condition characterized by a broad spectrum of disorders in the venous system. Varicose veins (VVs) represent a frequent clinical manifestation of CVeD, particularly in the lower limbs. Prior histopathological studies have defined a set of alterations observed in the venous wall of patients with VVs, affecting their structure and behavior. Metabolic changes in the veins appear to be a critical biological mechanism aiding our understanding of the pathogenesis of CVeD. In this sense, previous studies have identified a potential role of a glycolytic phenotype in the development of different vascular disorders; however, its precise role in CVeD remains to be fully explored. Thus, the aim of the present study was to analyze the gene and protein expression of glucose transporter 1 (GLUT-1) and the glycolytic enzymes PGK-1, ALD, GA3PDH and LDH in the VVs of patients with CVeD (n = 35) in comparison to those expressed in healthy subjects. Our results display enhanced gene and protein expression of GLUT-1, PGK-1, ALD, GA3PDH and LDH in patients with CVeD, suggesting a glycolytic switch of the venous tissue. Greater understanding of the impact of this glycolytic switch in patients with CVeD is required to define a possible pathophysiological role or therapeutic implications of these changes. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHRONICALLY ill
PHENOTYPES
VARICOSE veins
GLUCOSE transporters
PROTEIN expression
Subjects
Details
- Language :
- English
- ISSN :
- 20754426
- Volume :
- 12
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Personalized Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 159912701
- Full Text :
- https://doi.org/10.3390/jpm12101642