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Serological Evidence of Orthopoxvirus Infection in Neotropical Primates in Brazil.

Authors :
Abreu, Filipe Vieira Santos de
Lorene Soares Rocha, Kamila
Silva-Oliveira, Ramon
Macedo, Mariana Viana
Silva, Thamires Gabriele Macedo
Gonçalves-dos-Santos, Maria Eduarda
de Oliveira, Cirilo Henrique
Aquino-Teixeira, Sandy Micaele
Ottone, Vinícius de Oliveira
da Silva, Alex Junio Jardim
dos Santos, Ronaldo Medeiros
Tátila-Ferreira, Aline
Almeida, Marco Antônio Barreto de
dos Santos, Edmilson
da Cruz Cardoso, Jáder
Campos, Aline Alves Scarpellini
Albuquerque, George Rego
da Paixão Sevá, Anaiá
Ribeiro, Bergmann Morais
Simonini Teixeira, Danilo
Source :
Pathogens; Oct2022, Vol. 11 Issue 10, p1167-N.PAG, 7p
Publication Year :
2022

Abstract

The genus Orthopoxvirus (OPXV) of the family Poxviridae comprises several viruses that are capable of infecting a wide range of hosts. One of the most widespread OPXVs is the Vaccinia virus (VACV), which circulates in zoonotic cycles in South America, especially in Brazil, infecting domestic and wild animals and humans and causing economic losses as well as impacting public health. Despite this, little is known about the presence and/or exposure of neotropical primates to orthopoxviruses in the country. In this study, we report the results of a search for evidence of OPVX infections in neotropical free-living primates in the state of Minas Gerais, southeast Brazil. The sera or liver tissues of 63 neotropical primates were examined through plaque reduction neutralization tests (PRNT) and real-time PCR. OPXV-specific neutralizing antibodies were detected in two sera (4.5%) from Callithrix penicillata, showing 55% and 85% reduction in plaque counts, evidencing their previous exposure to the virus. Both individuals were collected in urban areas. All real-time PCR assays were negative. This is the first time that evidence of OPXV exposure has been detected in C. penicillata, a species that usually lives at the interface between cities and forests, increasing risks of zoonotic transmissions through spillover/spillback events. In this way, studies on the circulation of OPXV in neotropical free-living primates are necessary, especially now, with the monkeypox virus being detected in new regions of the planet. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20760817
Volume :
11
Issue :
10
Database :
Complementary Index
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
159901048
Full Text :
https://doi.org/10.3390/pathogens11101167