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Small-quantity lipid-based nutrient supplements, with or without added zinc, do not cause excessive fat deposition in Burkinabe children: results from a cluster-randomized community trial.
- Source :
- European Journal of Nutrition; Dec2022, Vol. 61 Issue 8, p4107-4120, 14p, 1 Diagram, 2 Charts, 1 Graph
- Publication Year :
- 2022
-
Abstract
- Purpose: Public health interventions to address stunting and wasting should be evaluated for possibly contributing to obesity risk. The present study tested the hypothesis that small-quantity lipid-based nutrient supplements (SQ-LNS) might increase fat deposition, and that additional zinc provided via SQ-LNS or in the form of dispersible tablets would increase fat-free mass (FFM) accretion. Methods: Using a two-stage, cluster-randomized trial design, 34 communities were randomly assigned to the intervention cohort (IC) or non-intervention cohort (NIC), and family compounds within the IC were randomly assigned to receive different amounts of zinc (0, 5 or 10 mg zinc) incorporated in SQ-LNS or 5 mg zinc in the form of dispersible tablets along with treatment for diarrhea, malaria and fever. Body composition was assessed in a subset of IC (n = 201) and NIC (n = 74) children at 9 and 18 months using the deuterium dilution method. A mixed linear model was used to examine average change in FFM and % fat mass (%FM) among intervention groups and by cohort. Results: Children in the IC had significantly greater change in FFM (Mean (95% Confidence Interval)) (1.57 (1.49, 1.64) kg) compared to the NIC (1.35 (1.23, 1.46) kg; p = 0.005). There were no significant differences in the change in %FM between the NIC and IC or among the intervention groups. Conclusion: SQ-LNS, along with morbidity treatment increased weight gain and FFM in young children from 9 to 18 months of age without increasing FM deposition. Additional zinc supplementation did not affect changes in FFM or %FM. Trial registration: The study was registered as a clinical trial with the US National Institute of Health (www.ClinicalTrials.gov; NCT00944281). [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG therapy for malaria
DRUG tablets
BODY composition
CONFIDENCE intervals
DIARRHEA
FEVER
LEAN body mass
NUTRITIONAL requirements
COMMUNITIES
DIETARY supplements
TREATMENT effectiveness
BURKINABE
RANDOMIZED controlled trials
COMPARATIVE studies
INFANT nutrition
DESCRIPTIVE statistics
ZINC
STATISTICAL sampling
CLUSTER analysis (Statistics)
LIPIDS
ADIPOSE tissues
LONGITUDINAL method
EVALUATION
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 61
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 159838919
- Full Text :
- https://doi.org/10.1007/s00394-022-02936-6