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Antibiotic desensitization as a potential tool in antimicrobial stewardship programs: retrospective data analysis and systematic literature review.

Antibiotic desensitization as a potential tool in antimicrobial stewardship programs: retrospective data analysis and systematic literature review.

Authors :
Rodríguez-Alarcón, Alicia
Barceló-Vidal, Jaime
Echeverría-Esnal, Daniel
Sorli, Luisa
Güerri-Fernández, Roberto
Ramis Fernández, Sofía Martina
Benitez-Cano, Adela
Sendra, Elena
López Montesinos, Inmaculada
Membrilla-Fernández, Estela
Ferrández, Olivia
Adalia, Ramón
Horcajada, Juan Pablo
Escolano, Fernando
Gómez-Zorrilla, Silvia
Grau, Santiago
Source :
Expert Review of Anti-infective Therapy; Nov2022, Vol. 20 Issue 11, p1491-1500, 10p
Publication Year :
2022

Abstract

Antibiotic allergy labels (AAL) are related to worse therapeutic results. Strategies to improve the management of these patients, such as the implementation of antibiotic desensitization, are essential for Antimicrobial Stewardship Programs (ASP). The aim of our study is to evaluate the efficacy and safety of antibiotic desensitization procedures for the management of patients with AAL. A retrospective study from 2015 to 2022 was performed to describe all antibiotic desensitization conducted in our institution, within the framework of ASP. A systematic literature review using electronic databases, such as PubMed, was also done to identify studies describing antibiotic desensitization between 2000 and 2022. Sixteen antibiotic desensitization protocols were carried out in our institution. In fourteen cases, the desensitization was successfully completed, and the antibiotic could be used to treat the infection. In the systematic review, twenty-two studies were included, with a total of 202 desensitization episodes. In 97% of them, the desensitization was completed successfully. No desensitization-related mortality was observed neither in our cohort nor in literature review. Antibiotic desensitization strategies should be considered a safe and effective tool that can be included in ASP for patients with a high risk of or confirmed allergy to penicillin. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14787210
Volume :
20
Issue :
11
Database :
Complementary Index
Journal :
Expert Review of Anti-infective Therapy
Publication Type :
Academic Journal
Accession number :
159811241
Full Text :
https://doi.org/10.1080/14787210.2022.2122443