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Expanding the Diversity of Pyridines Through Annulation of Keto and Diketo Compounds.
- Source :
- Asian Journal of Organic Chemistry; Oct2022, Vol. 11 Issue 10, p1-9, 9p
- Publication Year :
- 2022
-
Abstract
- An efficient gold [Au]‐catalyzed one‐pot synthesis has been developed for the construction of biologically interesting mono‐ and bipyridines by utilizing the commercially available cyclic ketones and propargylamine in a sealed tube. The formation of bipyridine derivative 21 a indicates that annulation followed by retro‐Diels–Alder reaction is occurring with norbornene system. However, keto‐derivatives containing bicyclo[2.2.2]octene system 25 indicate that retro‐Diels–Alder reaction is not facile. Compounds 32 a and 33 a were subjected to ring opening cross‐ metathesis to generate diversity and further functionalization of pyridine derivatives. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANNULATION
BIPYRIDINE derivatives
PYRIDINE derivatives
DIELS-Alder reaction
OCTENE
Subjects
Details
- Language :
- English
- ISSN :
- 21935807
- Volume :
- 11
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Asian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 159787695
- Full Text :
- https://doi.org/10.1002/ajoc.202200480