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mRNA vaccines: A novel weapon to control infectious diseases.

Authors :
Yuying Tian
Zhuoya Deng
Penghui Yang
Source :
Frontiers in Microbiology; 10/4/2022, Vol. 13, p1-16, 16p
Publication Year :
2022

Abstract

Infectious diseases have always threatened human life, but with the development of vaccines, effective strategies for preventing and controlling these diseases have become available. The global outbreak of COVID-19 ushered in the advent of mRNA vaccine technologies, which quickly led to the introduction of mRNA vaccines effective against SARS-CoV-2. The success of this approach has stimulated research into the use of mRNA vaccines in the fight against other emerging as well as remerging infectious diseases. This review examines the constructive strategies and delivery systems used in mRNA vaccines and provides an overview of current clinical trials of those vaccines in the prevention of infectious diseases. The underlying mechanisms of mRNA vaccines are also discussed, including the double-edged sword of the innate immune response. Finally, the challenges but also the potential of mRNA vaccines are considered. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1664302X
Volume :
13
Database :
Complementary Index
Journal :
Frontiers in Microbiology
Publication Type :
Academic Journal
Accession number :
159774339
Full Text :
https://doi.org/10.3389/fmicb.2022.1008684