Back to Search
Start Over
Amygdala subnuclei volumes, functional connectivity, and social–emotional outcomes in children born very preterm.
- Source :
- Cerebral Cortex Communications; 2022, Vol. 3 Issue 3, p1-8, 8p
- Publication Year :
- 2022
-
Abstract
- Children born very preterm can demonstrate social-cognitive impairments, which may result from limbic system dysfunction. Altered development of the subnuclei of the amygdala, stress-sensitive regions involved in emotional processing, may be key predictors of social-skill development. In a prospective cohort study, 7-year-old children born very preterm underwent neurodevelopmental testing and brain MRI. The Child Behavioral Checklist was used to assess social–emotional outcomes. Subnuclei volumes were extracted automatically from structural scans (n  = 69) and functional connectivity (n  = 66) was examined. General Linear Models were employed to examine the relationships between amygdala subnuclei volumes and functional connectivity values and social–emotional outcomes. Sex was a significant predictor of all social–emotional outcomes (P  < 0.05), with boys having poorer social–emotional outcomes. Smaller right basal nuclei volumes (B  = -0.043, P  = 0.014), smaller right cortical volumes (B  = -0.242, P  = 0.02) and larger right central nuclei volumes (B  = 0.85, P  = 0.049) were associated with increased social problems. Decreased connectivity strength between thalamic and amygdala networks and smaller right basal volumes were significant predictors of greater social problems (both, P  < 0.05), effects which were stronger in girls (P  = 0.025). Dysregulated maturation of the amygdala subnuclei, along with altered connectivity strength in stress-sensitive regions, may reflect stress-induced dysfunction and can be predictive of social–emotional outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- FUNCTIONAL connectivity
AMYGDALOID body
BASAL ganglia
LIMBIC system
SOCIAL problems
Subjects
Details
- Language :
- English
- ISSN :
- 26327376
- Volume :
- 3
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Cerebral Cortex Communications
- Publication Type :
- Academic Journal
- Accession number :
- 159753822
- Full Text :
- https://doi.org/10.1093/texcom/tgac028