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Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of action.
- Source :
- Genes & Genomics; Nov2022, Vol. 44 Issue 11, p1399-1404, 6p
- Publication Year :
- 2022
-
Abstract
- Background: The question of whether the coronavirus genome contain as-yetununderstood genetic component. Purpose (Objective): Elucidate the novel functions of the discovered tRNA-like base sequence and lead to the development of novel therapeutic agents. Methods: A novel tRNA-like base sequence was found in the sequences complementary to the genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV. By comparing mutations in the tRNA-like base sequences of these two viruses, it was found that base pairing in the cloverleaf model of SARS-CoV-2 was more robust than that of SARS-CoV. Results: The results of homology search between a short sequence of the coronavirus tRNA-like base sequence and human genes suggest that the molecule produced by this novel tRNA-like sequence may be involved in the splicing of human messenger RNA. Conclusions: Experimental molecular evidence of the tRNA-like base sequence discovered in this study is urgently needed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19769571
- Volume :
- 44
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Genes & Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 159684425
- Full Text :
- https://doi.org/10.1007/s13258-022-01299-w