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Mechanism of the serum defect in yeast opsonization in children with fulminant hepatic failure (FHF).
- Source :
- Clinical & Experimental Immunology; Nov1981, Vol. 46 Issue 2, p406-411, 6p
- Publication Year :
- 1981
-
Abstract
- Defective opsonization of heat-killed baker's yeast was found in all 14 children with fulminant hepatic failure (FHF) but returned to normal in two who recovered and was normal in six mothers of patients. Yeast opsonization was significantly correlated with factor B activity of FHF serum but not with other components of classical or alternative pathways of complement. Reconstitution and family studies suggested that defective yeast opsonization in FHF is secondary and, although dependent on factor B activity, is qualitatively and quantitatively similar to that of primary yeast opsonization deficiency. These findings suggest that the factors responsible for opsonization of yeasts, or their regulation, are synthesized or controlled by the liver. [ABSTRACT FROM AUTHOR]
- Subjects :
- YEAST
LEAVENING agents
PATIENTS
BLOOD plasma
SERUM
LIVER
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 46
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15957067