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Development of Parkinsonism in a Patient with Central Pontine Myelinolysis.

Authors :
Antonioni, Annibale
Rispoli, Vittorio
Fazio, Patrik
Golfrè Andreasi, Nico
Govoni, Vittorio
Granieri, Enrico
Source :
Neurology International; Sep2022, Vol. 14 Issue 3, p673-677, 5p
Publication Year :
2022

Abstract

Osmotic demyelination syndrome (ODS) is caused by damage to the pons myelin sheath and nerve cells. Although the pathophysiological mechanism responsible for the damage is not yet fully understood, it is currently believed that osmotic-type changes (especially if they are massive and too rapid) cause oedema that leads to compression and, subsequently, demyelination of white matter fibres. It generally manifests with acute paraparesis/tetraparesis, dysphagia, dysarthria, diplopia, and loss of consciousness, as well as hallucinations, spasms, and other neurological symptoms related to brainstem damage. In extreme cases, the locked-in syndrome may also appear. Of note, in some cases an association between osmotic demyelinating damage and the onset of movement disorders has been documented and, although the pathophysiology is still unknown, a correlation has been postulated between ODS and movement disorders. Here, we present a patient with ODS who developed parkinsonism, thus supporting the hypothesis of a correlation between these pathological events. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20358377
Volume :
14
Issue :
3
Database :
Complementary Index
Journal :
Neurology International
Publication Type :
Academic Journal
Accession number :
159330506
Full Text :
https://doi.org/10.3390/neurolint14030055