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Pinocembrin polymeric micellar drug delivery system: preparation, characterisation and anti-hyperuricemic activity evaluation.
- Source :
- Journal of Microencapsulation; Aug2022, Vol. 39 Issue 5, p419-432, 14p
- Publication Year :
- 2022
-
Abstract
- Aim: Hydrophobic pinocembrin (PCB) was incorporated into a new nano-drug delivery system to enhance solubility, bioavailability and anti-hyperuricemic activity of the drug. Methods: We fabricated PCB loaded polymeric micelles (PCB-FPM) by thin film dispersion method and appropriately determined their physical characteristics. The oral relative bioavailability and anti-hyperuricemic activity of PCB-FPM and free PCB were observed. Results: The optimum particle size of the micelles was 19.90 ± 0.93 nm. PCB-FPM exhibited great stability within 18 days, coupled with lower cytotoxicity and higher biocompatibility. Moreover, the percent cumulative release of PCB-FPM was much higher than free PCB in the dissolution media. The oral bioavailability of PCB-FPM was increased by 2.61 times compared with free PCB. Uric acid (UA) level of rats was reduced in PCB-FPM group (200 mg/kg) by 78.82% comparable to the model control. Conclusion: PCB-FPM may become an ideal strategy to increase oral in-vivo availability and anti-hyperuricemic activity of PCB. [ABSTRACT FROM AUTHOR]
- Subjects :
- POLYMERIC drug delivery systems
DRUG delivery systems
URIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 02652048
- Volume :
- 39
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Microencapsulation
- Publication Type :
- Academic Journal
- Accession number :
- 159267440
- Full Text :
- https://doi.org/10.1080/02652048.2022.2096138