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Pain as Initial Presenting Symptom Is Associated With Delay to Seeking Medical Attention, Higher Risk of Relapse, and Shorter Survival in Patients With Early-Stage Extremity or Trunk Synovial Sarcoma.
- Source :
- Permanente Journal; 2022, Vol. 26 Issue 3, p94-102, 9p
- Publication Year :
- 2022
-
Abstract
- BACKGROUND: Whether the presenting symptom of pain vs mass impacts survival of early-stage synovial sarcoma is not known. PATIENTS AND METHODS: The authors investigated patients with early-stage extremity/trunk synovial sarcoma diagnosed from 2005 to 2017 at Kaiser Permanente Northern California for associations between the presenting symptom and survival. RESULTS: Among 56 patients with early-stage extremity/trunk synovial sarcoma, median disease-free survival (DFS) was 20.3 months for the pain-only group (n = 19) vs 50.5 months for the mass ± pain group (n = 37) (p = 0.004), and median overall survival (OS) was 35.7 months vs 53.9 months (p = 0.009), respectively. Median DFS was 26.9 months for the pain ± mass group (n = 32) vs 48.6 months for the mass-only group (n = 24) (p = 0.047), whereas OS was not significantly different (49.6 vs. 53.6 months, p = 0.282). Pain at presentation was associated with a higher incidence of deep tumors and a higher risk of relapse. Cox regression model adjusting for age, sex, race, tumor location, tumor size, and wait-time to seek medical attention showed that pain at presentation was associated with 3-fold worse DFS and OS. CONCLUSION: Pain at presentation was an adverse risk factor for patients with early-stage extremity/trunk synovial sarcoma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15525767
- Volume :
- 26
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Permanente Journal
- Publication Type :
- Academic Journal
- Accession number :
- 159207349
- Full Text :
- https://doi.org/10.7812/TPP/21.199