Back to Search Start Over

The role and regulatory mechanism of m6A methylation in the nervous system.

Authors :
Lingling Jiang
Xiaoheng Li
Shasha Wang
Zengqiang Yuan
Jinbo Cheng
Source :
Frontiers in Genetics; 9/1/2022, Vol. 13, p1-14, 14p
Publication Year :
2022

Abstract

N6-methyladenosine (m6A) modification regulates RNA translation, splicing, transport, localization, and stability at the post-transcriptional level. The m6A modification has been reported to have a wide range of effects on the nervous system, including neurogenesis, cerebellar development, learning, cognition, and memory, as well as the occurrence and development of neurological disorders. In this review, we aim to summarize the findings on the role and regulatory mechanism of m6A modification in the nervous system, to reveal the molecular mechanisms of neurodevelopmental processes, and to promote targeted therapy for nervous system-related diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16648021
Volume :
13
Database :
Complementary Index
Journal :
Frontiers in Genetics
Publication Type :
Academic Journal
Accession number :
159206349
Full Text :
https://doi.org/10.3389/fgene.2022.962774