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Inflammatory and blood gas markers of COVID-19 delirium compared to non-COVID-19 delirium: a cross-sectional study.
- Source :
- Aging & Mental Health; Oct2022, Vol. 26 Issue 10, p2054-2061, 8p, 1 Diagram, 2 Charts
- Publication Year :
- 2022
-
Abstract
- We aimed to find the association of inflammation and respiratory failure with delirium in COVID-19 patients. We compare the inflammatory and arterial blood gas markers between patients with COVID-19 delirium and delirium in other medical disorders. This cross-sectional study used the CHART-DEL, a validated research tool, to screen patients for delirium retrospectively from clinical notes. Inflammatory markers C-reactive protein (CRP) and white cell count (WBC), and the partial pressures of oxygen (PO<subscript>2</subscript>) and carbon dioxide (PCO<subscript>2</subscript>) were compared between patients with COVID-19 delirium and delirium in other medical disorders. In bivariate analysis, CRP (mg/L) was significantly higher in the COVID-19 group, (81.7 ± 80.0 vs. 58.8 ± 87.7, p = 0.04), and WBC (10<superscript>9</superscript>/L) was significantly lower (7.44 ± 3.42 vs. 9.71 ± 5.45, p = 0.04). The geometric mean of CRP in the COVID-19 group was 140% higher in multiple linear regression (95% CI = 7–439%, p = 0.03) with age and sex as covariates. There were no significant differences in pO<subscript>2</subscript> or pCO<subscript>2</subscript> across groups. The association between higher CRP and COVID-19 in patients with delirium may suggest an inflammatory basis for delirium in COVID-19. Our findings may assist clinicians in establishing whether delirium is due to COVID-19, which may improve management and outcomes of infected patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- RISK of delirium
BIOMARKERS
C-reactive protein
STATISTICS
COVID-19
RESPIRATORY insufficiency
BLOOD gases analysis
CONFIDENCE intervals
OXYGEN
INFLAMMATION
CROSS-sectional method
RESEARCH methodology
MULTIPLE regression analysis
ACQUISITION of data
RETROSPECTIVE studies
RISK assessment
DELIRIUM
MEDICAL records
LEUKOCYTE count
DESCRIPTIVE statistics
CARBON dioxide
LONGITUDINAL method
PARTIAL pressure
Subjects
Details
- Language :
- English
- ISSN :
- 13607863
- Volume :
- 26
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Aging & Mental Health
- Publication Type :
- Academic Journal
- Accession number :
- 159104312
- Full Text :
- https://doi.org/10.1080/13607863.2021.1989375