Back to Search Start Over

High levels of C‐reactive protein‐to‐albumin ratio (CAR) are associated with a poor prognosis in patients with severe fever with thrombocytopenia syndrome in early stage.

Authors :
Liu, Zishuai
Zhang, Rongling
Zhou, Wei
Ma, Ruize
Han, Leqiang
Zhao, Zhe
Ge, Ziruo
Ren, Xingxiang
Zhang, Wei
Sun, Aijun
Chen, Zhihai
Source :
Journal of Medical Virology; Nov2022, Vol. 94 Issue 11, p5375-5384, 10p
Publication Year :
2022

Abstract

C‐reactive protein‐to‐albumin ratio (CAR) can be used to assess the prognosis of various diseases. This study aimed to evaluate the relationship between CAR on the prognosis of patients with severe fever with thrombocytopenia syndrome (SFTS). This study included 155 SFTS patients from the Public Health Clinical Center of Dalian from January to December 2021. They were divided into survival and deceased groups based on the clinical prognosis. The independent risk factors for poor prognosis of SFTS patients at an early stage were determined by Cox regression. The efficacy of CAR prediction was assessed by the receiver operating characteristic (ROC) curve. A total of 155 patients were included in this study, with an average age of 61.98± 11.70 years, including 77 males and 65 females. The mortality rate of the patients enrolled in this study was 14.19%. Multivariate Cox regression indicated that CAR (hazard ratio = 2.585, 95% confidence interval [CI] 1.405–4.753, p = 0.002) could be an independent predictor for prognosis in SFTS patients at an early stage. CAR had an AUC of 0.781 (95% CI, 0.665–0.898, p = 0.000), a cutoff value of 0.57, a sensitivity of 0.77, and a specificity of 0.80, with better predictive efficacy, compared to neutrophil‐to‐lymphocyte ratio (NLR). High levels of CAR are associated with poor prognosis in SFTS patients, and CAR can be used as an independent predictor for SFTS patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01466615
Volume :
94
Issue :
11
Database :
Complementary Index
Journal :
Journal of Medical Virology
Publication Type :
Academic Journal
Accession number :
159085638
Full Text :
https://doi.org/10.1002/jmv.27972