Conversions of 2-(2-Oxo CyclohexylcarbonyOBenzoic Acid Derivatives to Pyrazolo[5,1-a]lsoindole and Pyrimidine Rings.

Phtalic acid derivative of o-methylcarboxybenzoylchioride readily acylates N(1-cyclohexenyl) morpholine and is likely to acylate other enamines along the classic path to 1,3-diketones. It is a convenient route towards o-(1,3-diketone)) derivatives of benzoic acid, which are, precursors of o-(heteroaryl)-benzoic acids. Further conversions with hydrazines and amidines lead to pyrazolo[5.1-a]isoindole and pyrimidine rings respectively. The structures of the obtained compounds were con. firmed by X-ray structure determinations. [ABSTRACT FROM AUTHOR]