KETOGENIC DIET AND GENETIC DIS ORDERS.

Ketogenic Diet (KD) represents a specific type of diet which is based on the process of ketosis. Even since 1925, KD began to be used as a treatment for drug-resistant epilepsy but recently, KD has begun to take part in the treatment of many chronic diseases. In this review we look at the role and the implications of KD in some genetic disorders: pharmacoresistant epilepsy, Alzheimer's disease, Angelman syndrome, glucose transporter type 1 deficiency syndrome (Glut1-DS), glycogen storage diseases (GSDs) and pyruvate dehydrogenase complex deficiency (PDCD). The review aims to provide clinicians a snapshot of the genetic factors that could have an impact on the response to patient's response to KD. As genetic variants may influence the response to KD, the implementation of nutrigenomics in the personalized nutrition of the patient with KD would be the key for the best patient care. [ABSTRACT FROM AUTHOR]