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The Presence of Anti-Protein A Antibodies in Patients with Rheumatoid Arthritis.
- Source :
- Scandinavian Journal of Immunology; May1991, Vol. 33 Issue 5, p585-592, 8p
- Publication Year :
- 1991
-
Abstract
- Sixteen patients with rheumatoid arthritis (RA) were examined for the presence of anti-protein A antibodies. The F(ab')<subscript>2</subscript> preparations from five RA patients showed significant binding to IgG-free protein A on ELISA. The protein A binding was further examined by immunoblotting. The F(ab')<subscript>2</subscript> preparations of high protein A-binding protein gave a specific reaction with IgG-free protein A on nitrocellulose paper. This demonstrates the presence of anti-protein A antibodies in patients with RA. Those RA patients with anti-protein A antibodies had more active disease as judged by the Lansbury's activity index. The level of serum rheumatoid factor (RAHA) was significantly higher in patients with anti-protein A antibodies than in those without anti-protein A antibodies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 33
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15895488
- Full Text :
- https://doi.org/10.1111/j.1365-3083.1991.tb02530.x