Patch testing for cutaneous adverse drug reactions in a paediatric population: A retrospective review.

Antibiotics, case series, children, cutaneous adverse drug reactions, drug hypersensitivity, maculopapular exanthema, patch test, DRESS syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis Keywords: antibiotics; case series; children; cutaneous adverse drug reactions; DRESS syndrome; drug hypersensitivity; maculopapular exanthema; patch test; Stevens-Johnson syndrome; toxic epidermal necrolysis EN antibiotics case series children cutaneous adverse drug reactions DRESS syndrome drug hypersensitivity maculopapular exanthema patch test Stevens-Johnson syndrome toxic epidermal necrolysis 373 376 4 09/08/22 20221001 NES 221001 Non-immediate cutaneous adverse drug reactions (CADRs) are mostly clinical manifestations of a Type IV hypersensitivity reaction.1,2 In children, diagnosing CADRs is a common challenge for physicians, as childhood rashes are more often due to viral infections but frequently mimic CADRs.1,2 A proper diagnosis and identification of the culprit drug avoids misdiagnosis, therefore, preventing unnecessary drug avoidance or replacement, and guides for potential alternatives reducing morbidity from CADRs.1-3 Patch tests (PT) are considered useful for diagnosing non-immediate CADRs, however, few paediatric studies have been published.2-6 This may be related to the lower incidence of CADRs in children, the lack of PT standardization especially for severe cutaneous adverse reactions (SCARs) and controversies on PT safety, particularly in this population.3-5,7 This study aimed to evaluate the sensitivity and safety of PT for paediatric CADRs. [Extracted from the article]