Is genotoxicity a suitable biomarker for varicocele?

I read the recent paper published in the I Andrologia i titled 'Effect of varicocele on sperm DNA damage: A systematic review and meta-analysis' by Zhang et al. (2022). In this study, the authors concluded that 'In conclusion, patients diagnosed with clinical varicocele had higher DNA fragmentation índex than healthy controls, which means varicocele could impair sperm DNA, consequently the fertility potential of affected men'. Certainly, such information would contribute to better understand if, and to what extent, varicocele induces cyto- and/or genotoxicity in sperm cells as a result of DNA fragmentation in sperm cells. [Extracted from the article]