Vitamin C Deficiency in Blood Samples of COVID-19 Patients.

In the present study, the plasma levels of four SARS-CoV-2 associated vitamins (ascorbate, retinol, calcidiol, and -tocopherol) were measured in COVID-19 patients with varying disease severity and compared with the respective levels in healthy controls. (A) Time until the end of either ventilation time, (B) hospitalization, or (C) a COVID-19 related death event based on the widely accepted cut-off for vitamin C deficiency (plasma ascorbate of 11.4 µM) for the 74 COVID-19 cases. p-values are calculated by the Gehan-Breslow-Wilcoxon test. (D) ROC analysis for the differentiation of healthy controls and mild COVID-19 cases based on plasma ascorbate. The data gathered herein did not show a COVID-19 specific decrease in blood calciferol or retinol as previously reported for COVID-19 [[31], [44]], whereas the data confirmed previous investigations reporting decreased plasma ascorbate in COVID-19 cases [[45], [47]] and the absence of relation between calcidiol and COVID-19 severity [[48]]. Keywords: COVID-19; vitamin plasma levels; ascorbate; calcidiol; retinol; -tocopherol EN COVID-19 vitamin plasma levels ascorbate calcidiol retinol -tocopherol N.PAG N.PAG 14 08/29/22 20220801 NES 220801 1. [Extracted from the article]